The RPG-7 appears as the RPG in Call of Duty: Black Ops. The cross-hair remains the same as it was in Modern Warfare 2, as do the iron sights. The RPG comes with a rocket in the chamber and another reloadable rocket (2 total). However, if the tier one perkScavenger is upgraded to the Pro version, which spawns the player with increased ammunition with their weapons, the RPG will start with one in the chamber and two reloadable rockets (3 total).

The RPG in Call of Duty: Black Ops packs less damage than the other RPGs in Call of Duty games, especially with the reappearance of Flak Jacket. Despite this reduction, it is still useful for taking out groups of enemies with one rocket. Beware however, the RPG is wildly inaccurate when fired at medium to long distance, often veering away from the intended target. The weapon is decent for taking outAttack Helicopters, because if the player has a clear shot, it will take only one rocket. Nonetheless, it has a large chance of missing due to its above mentioned accuracy. Other targets such as the Chopper Gunner are nearly impossible to take down, so a Strela-3 is more suited for anti-air roles.

Due to a patch, on the PlayStation 3, PC and Xbox 360 versions of the game, in Gun Game, the Grim Reaper was replaced by the RPG-7 in tier 16 until late April of 2011, when a new patch fixed the glitch and the Grim Reaper replaced the RPG. On the Wii version of the game, the Grim Reaper persists.

It also appears in Dead Ops Arcade as a pick-up. The player can use it for several seconds as a fully automatic weapon. It can penetrate through hordes of zombies when shot at, and will explode short after.